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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1919 2
1945 13
1946 96
1947 84
1948 70
1949 47
1950 123
1951 155
1952 168
1953 220
1954 188
1955 207
1956 284
1957 405
1958 446
1959 375
1960 260
1961 281
1962 394
1963 870
1964 1048
1965 624
1966 470
1967 605
1968 785
1969 922
1970 1061
1971 1142
1972 1297
1973 1362
1974 1400
1975 1275
1976 1245
1977 1166
1978 1162
1979 1414
1980 1294
1981 1572
1982 1858
1983 1798
1984 2025
1985 2020
1986 1995
1987 1842
1988 1816
1989 2064
1990 2036
1991 2043
1992 2041
1993 2030
1994 1894
1995 2621
1996 3253
1997 3444
1998 3634
1999 3794
2000 4098
2001 4296
2002 4623
2003 5009
2004 5152
2005 5667
2006 6228
2007 6801
2008 6971
2009 7271
2010 7719
2011 8178
2012 8827
2013 8562
2014 8940
2015 8925
2016 8885
2017 8813
2018 8703
2019 8591
2020 8767
2021 7533
2022 7196
2023 6086
2024 2665

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221,217 results

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Page 1
Recent advances in β-lactam synthesis.
Hosseyni S, Jarrahpour A. Hosseyni S, et al. Org Biomol Chem. 2018 Oct 3;16(38):6840-6852. doi: 10.1039/c8ob01833b. Org Biomol Chem. 2018. PMID: 30209477 Review.
Traditional methods for beta-lactam synthesis usually involved amide bond formation and the Staudinger reaction. In recent years, by the advancement of photo- and transition metal-catalysis, several new methods have been reported for beta-lactam synthesis. For instance: li …
Traditional methods for beta-lactam synthesis usually involved amide bond formation and the Staudinger reaction. In recent years, by …
Clinical pharmacology of bimatoprost.
Cantor LB. Cantor LB. Expert Opin Drug Metab Toxicol. 2005 Jun;1(1):151-7. doi: 10.1517/17425255.1.1.151. Expert Opin Drug Metab Toxicol. 2005. PMID: 16922657 Review.
Bimatoprost (Lumigan), Allergan) is a highly efficacious ocular hypotensive agent that provides good diurnal control of intraocular pressure in glaucoma and ocular hypertensive patients. ...
Bimatoprost (Lumigan), Allergan) is a highly efficacious ocular hypotensive agent that provides good diurnal control of intraocular p …
An Iodide-Mediated Anodic Amide Coupling.
Großmann LM, Beier V, Duttenhofer L, Lennartz L, Opatz T. Großmann LM, et al. Chemistry. 2022 Sep 27;28(54):e202201768. doi: 10.1002/chem.202201768. Epub 2022 Aug 22. Chemistry. 2022. PMID: 35835720 Free PMC article.
The ubiquity of amide bonds, present in natural products and common pharmaceuticals renders this functional group one of the most prevalent in organic chemistry. Despite its importance and a wide variety of existing methods for its formation, the latter still can be a chal …
The ubiquity of amide bonds, present in natural products and common pharmaceuticals renders this functional group one of the most pre …
Two-Component Redox Organocatalyst for Peptide Bond Formation.
Handoko, Panigrahi NR, Arora PS. Handoko, et al. J Am Chem Soc. 2022 Mar 2;144(8):3637-3643. doi: 10.1021/jacs.1c12798. Epub 2022 Feb 21. J Am Chem Soc. 2022. PMID: 35188383
Yet, modern peptide synthesis remains atom uneconomical and requires an excess of coupling agents and protected amino acids for efficient amide bond formation. ...The new method utilizes a two-component organoreductant/organooxidant-recycling strategy to catalyze …
Yet, modern peptide synthesis remains atom uneconomical and requires an excess of coupling agents and protected amino acids for effic …
Selected plant triterpenoids and their amide derivatives in cancer treatment: A review.
Özdemir Z, Wimmer Z. Özdemir Z, et al. Phytochemistry. 2022 Nov;203:113340. doi: 10.1016/j.phytochem.2022.113340. Epub 2022 Aug 17. Phytochemistry. 2022. PMID: 35987401 Review.
This review article sheds light on four selected triterpenoids, oleanolic, ursolic, betulinic and platanic acid, and on their amide derivatives as important natural or semisynthetic agents in cancer treatment, and, in part, in pathogenic microbe treatment. ...Mainly …
This review article sheds light on four selected triterpenoids, oleanolic, ursolic, betulinic and platanic acid, and on their amide d …
Ropivacaine: a pharmacological review.
Hansen TG. Hansen TG. Expert Rev Neurother. 2004 Sep;4(5):781-91. doi: 10.1586/14737175.4.5.781. Expert Rev Neurother. 2004. PMID: 15853505 Review.
Ropivacaine (Naropin, AstraZeneca) a new long-acting amide local anaesthetic agent, is a pure S-enantiomer, with a high pKa and relatively low-lipid solubility. ...In conclusion, ropivacaine appears to be a safer local anaesthetic agent than bupivacaine. It s …
Ropivacaine (Naropin, AstraZeneca) a new long-acting amide local anaesthetic agent, is a pure S-enantiomer, with a high pKa an …
A review on favipiravir: the properties, function, and usefulness to treat COVID-19.
Hashemian SM, Farhadi T, Velayati AA. Hashemian SM, et al. Expert Rev Anti Infect Ther. 2021 Aug;19(8):1029-1037. doi: 10.1080/14787210.2021.1866545. Epub 2020 Dec 29. Expert Rev Anti Infect Ther. 2021. PMID: 33372567 Review.
Favipiravir has a wide range of activity against many single-stranded RNA viruses, is well tolerated in humans and has a high barrier to resistance. However, high doses of the agent are necessary to obtain an efficient antiviral activity. Favipiravir is teratogen in pregna …
Favipiravir has a wide range of activity against many single-stranded RNA viruses, is well tolerated in humans and has a high barrier to res …
Enzymatic Strategies for the Biosynthesis of N-Acyl Amino Acid Amides.
Kua GKB, Nguyen GKT, Li Z. Kua GKB, et al. Chembiochem. 2024 Feb 16;25(4):e202300672. doi: 10.1002/cbic.202300672. Epub 2024 Jan 5. Chembiochem. 2024. PMID: 38051126 Review.
Their conventional chemical synthesis involves the use of toxic chlorinating agents for carboxylic acid activation. Enzyme-catalyzed biotransformation for the green synthesis of these amides is therefore highly desirable. ...Recently, the development of an alternati …
Their conventional chemical synthesis involves the use of toxic chlorinating agents for carboxylic acid activation. Enzyme-catalyzed …
Recent progress in prodrug design strategies based on generally applicable modifications.
Hamada Y. Hamada Y. Bioorg Med Chem Lett. 2017 Apr 15;27(8):1627-1632. doi: 10.1016/j.bmcl.2017.02.075. Epub 2017 Mar 2. Bioorg Med Chem Lett. 2017. PMID: 28285913 Review.
The development of prodrugs has progressed with the aim of improving drug bioavailability by overcoming various barriers that reduce drug benefits in clinical use, such as stability, duration, water solubility, side effect profile, and taste. Many conventional drugs act as the pr …
The development of prodrugs has progressed with the aim of improving drug bioavailability by overcoming various barriers that reduce drug be …
Valproic Acid and Its Amidic Derivatives as New Antivirals against Alphaherpesviruses.
Andreu S, Ripa I, Bello-Morales R, López-Guerrero JA. Andreu S, et al. Viruses. 2020 Nov 26;12(12):1356. doi: 10.3390/v12121356. Viruses. 2020. PMID: 33256172 Free PMC article. Review.
Valproic acid (VPA) is a branched short-chain fatty acid clinically used as a broad-spectrum antiepileptic drug in the treatment of neurological disorders, which has shown promising antiviral activity against some herpesviruses. Moreover, its amidic derivatives valpromide …
Valproic acid (VPA) is a branched short-chain fatty acid clinically used as a broad-spectrum antiepileptic drug in the treatment of neurolog …
221,217 results
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